Tremain Smith has four works in the permanent collection of the Metropolitan Museum of Art in New York. Her work is in corporate and private collections across the country. She has had dozens of solo exhibitions in New York, Los Angeles, Chicago, Atlanta, Philadelphia, Scottsdale, Maine, Delaware, Florida and Hawaii. Group exhibitions include SOFA Chicago, Art Miami, the Painted Bride, the Philadelphia Art Alliance, and the USArtists American Fine Art Show. Smith was awarded a 3-month artist residency in 2004 at the McColl Center for Visual Art in Charlotte, North Carolina. In 2006 she was an instructor in encaustic painting at the Penland School of Crafts in Penland, NC.

Smith has been reviewed extensively including coverage by the Philadelphia Inquirer, the Chicago Tribune and the LA Weekly. Her work is included in The Art of Encaustic Painting Contemporary Expression in the Ancient Medium of Pigmented Wax published by Watson-Guptill, and in the art journal New American Paintings. Smith studied at the Pennsylvania Academy of Fine Arts, Tyler School of Art, Carnegie-Mellon University and the University of Pennsylvania.

Alongside her studio work, Tremain lectures, leads community workshops and teaches art through various venues, particularly in the Philadelphia area.